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- c-Myc Antibodies
Proteintech
View all (111) c-Myc antibodies
Cite c-MYC Polyclonal Antibody, CoraLite® Plus 647
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c-MYC Antibody (CL647-10828) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.2 µg CoraLite® Plus 647 Anti-Human c-MYC (CL647-10828) (red), or 0.2 µg Isotype Control (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Product Details
CL647-10828
Applications
Tested Dilution
Publications
Flow Cytometry(Flow)
0.2 µg/1x10^6 cell suspension
-
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
CoraLite® Plus 647
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP LSPSRRSGLC SPSYVAVTPF SLRGDNDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSG SPNPARGHSV CSTSSLYLQD LSAAASECID PSVVFPYPLN DSSSPKSCAS QDSSAFSPSS DSLLSSTESS PQGSPEPLVL HEETPPTTSS DSEEEQEDEE EIDVVSVEKR QAPGKRSESG SPSAGGHSKP PHSPLVLKRC HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT EENVKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQAEE QKLISEEDLL RKRREQLKHK LEQLRNSCA
Target Information
The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases:avian myelocytomatosis viral oncogene hom*olog; bHLHe39; c Myc; c-myc epitope tag; Class E basic helix-loop-helix protein 39; cmyc; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; Proto-oncogene c-Myc; Transcription factor p64; v-myc myelocytomatosis viral oncogene hom*olog
UniProt ID:(Human) P01106
Entrez Gene ID:(Human) 4609
Molecular Function: basic helix-loop-helix transcription factor
Function(s)
negative regulation of transcription from RNA polymerase II promoterMAPK cascadebranching involved in ureteric bud morphogenesispositive regulation of mesenchymal cell proliferationenergy reserve metabolic processchromatin remodelingtranscription from RNA polymerase II promotercellular iron ion homeostasiscellular response to DNA damage stimuluscell cycle arrestNotch signaling pathwaypositive regulation of cell proliferationresponse to gamma radiationregulation of gene expressionoxygen transportregulation of telomere maintenancenegative regulation of stress-activated MAPK cascadecellular response to UVcellular response to drugresponse to drugnegative regulation of apoptotic processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic processfibroblast apoptotic processnegative regulation of monocyte differentiationpositive regulation of transcription, DNA-templatedpositive regulation of transcription from RNA polymerase II promoterpositive regulation of fibroblast proliferationnegative regulation of fibroblast proliferationpositive regulation of epithelial cell proliferationchromosome organizationnegative regulation of cell divisioncanonical Wnt signaling pathwayresponse to growth factorpositive regulation of metanephric cap mesenchymal cell proliferationbeta-catenin-TCF complex assemblypositive regulation of DNA biosynthetic processpositive regulation of response to DNA damage stimulus
Process(es)
RNA polymerase II core promoter proximal region sequence-specific DNA bindingtranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingDNA bindingtranscription factor activity, sequence-specific DNA bindingprotein bindingtranscription factor bindingprotein complex bindingprotein dimerization activityrepressing transcription factor bindingE-box binding
It has to be done as per old AB suggested Products section.